Biomedical sciences publications
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Evaluation of dimethandrolone undecanoate in non-human primates as a candidate for long-acting injectable male contraceptive
The objective is to assess the safety, pharmacokinetics (PK), and long-acting contraceptive potential of Dimethandrolone undecanoate when delivered as an injectable or oral formulation.
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Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood
We examined the associations between alcohol use and ventral tegmental area resting-state functional connectivity to subcortical structures in 796 participants across 9 waves of longitudinal data from the National Consortium…
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The Need to Enrich Population Diversity in Radiogenomic Research
In radiogenomics, where the aim is to identify germline (as opposed to somatic) genetic markers predictive of response to radiation therapy, most studies accrued subjects primarily of European ancestry.
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Multi-domain predictors of grip strength differentiate individuals with and without alcohol use disorder
Grip strength is considered one of the simplest and reliable indices of general health. Although motor ability and strength are commonly affected in people with alcohol use disorder (AUD), factors…
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Resting-state fMRI activation is associated with phenotypic features of autism in early adolescence
In this study, we aimed to explore if activation in brain regions of the default mode network (DMN), specifically the medial prefrontal cortex (MPC), posterior cingulate cortex (PCC), superior temporal…
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Aging, HIV infection, and alcohol exert synergist effects on regional thalamic volumes resulting in functional impairment
Regional thalamic volumetry detected normal aging declines, differential and accelerated volume losses in HIV, relations between age-related nuclear and performance declines, and exacerbation of volume declines in comorbid alcohol use…
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Anterior and Posterior Thalamic Nuclei Correlates of Memory, Attention, and Motor Processes in HIV Infection and Alcohol Use Disorder Comorbidity
Here, we examined relations between thalamic subregions (anterior, ventral, medial, and posterior) and neuropsychological functions (attention/working memory, executive functioning, episodic memory, and motor skills) in relation to HIV and alcohol…
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Menstruation Problems and Sleep Interactions: Implications for the Mental Health of Adolescent Females
Internalizing symptoms are associated with menstrual cycle characteristics and menstrual pain in female adolescents, especially in those with shorter sleep and later bedtimes. The relationship between the menstrual cycle, sleep,…
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Menstrual Cycle Variations in Wearable-Detected Finger Temperature and Heart Rate, But Not in Sleep Metrics, in Young and Midlife Individuals
We use wearable and diary-based data to investigate menstrual phase and age effects on finger temperature, sleep, heart rate (HR), physical activity, physical symptoms, and mood.
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A Longitudinal Study of the Relationship Between Alcohol-Related Blackouts and Attenuated Structural Brain Development
Alcohol-related blackouts (ARBs) are common in adolescents and emerging adults. ARBs may also be indicative of persistent, alcohol-related neurocognitive changes. This study explored ARBs as a predictor of altered structural…
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Metadata-conditioned generative models to synthesize anatomically-plausible 3D brain MRIs
To generate high-quality T1-weighted MRIs relevant for neuroscience discovery, we present a two-stage Diffusion Probabilistic Model (called BrainSynth) to synthesize high-resolution MRIs conditionally-dependent on metadata (such as age and sex).…
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Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces
This study assesses the temporal evolution of MRI-visible perivascular spaces (MV-PVS) volume in adolescents and young adults, and secondarily evaluates the relationship between MV-PVS, age, sex, and body mass index…